Glutathione peroxidase 4-regulated neutrophil ferroptosis induces systemic autoimmunity

Li, PC; Jiang, MD; Li, KT; Li, H; Zhou, YZ; Xiao, XY; Xu, Y; Krishfield, S; Lipsky, PE; Tsokos, GC; Zhang, X

Tsokos, GC (corresponding author), Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02115 USA.; Lipsky, PE (corresponding author), RILITE Res Inst, Charlottesville, VA 28217 USA.; Lipsky, PE (corresponding author), AMPEL BioSolut, Charlottesville, VA 28217 USA.; Zhang, X (corresponding author), Chinese Acad Med Sci, Beijing Hosp, Inst Geriatr Med, Dept Rheumatol, Beijing, Peoples R China.

NATURE IMMUNOLOGY, 2021; 22 (9): 1107

Abstract

Zhang and colleagues identify a role for cell death by glutathione peroxidase 4 (GPX4)-regulated ferroptosis in neutrophils from patients with systemi......

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